USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: APOA1_HUMAN USC-OGP 2-DE database:  APOA1_HUMAN APOA1_HUMAN General information about the entry View entry in simple text format Entry name APOA1_HUMAN Primary accession number P02647 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Apolipoprotein A-I; Short=Apo-AI; Short=ApoA-I; AltName: Full=Apolipoprotein A1; Contains: RecName: Full=Proapolipoprotein A-I; Short=ProapoA-I; Contains: RecName: Full=Truncated apolipoprotein A-I; AltName: Full=Apolipoprotein A-I(1-242); Flags: Precursor;. Gene name Name=APOA1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0812: pI=5.30; Mw=24872 Cross-references UniProtKB/Swiss-Prot P02647; APOA1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name APOA1_HUMAN Primary accession number P02647 Secondary accession number(s) A8K866 Q6LDN9 Q6Q785 Q9UCS8 Q9UCT8 Sequence was last modified on  July 21, 1986 (version 1) Annotations were last modified on  March 15, 2017 (version 223) Name and origin of the protein Description RecName: Full=Apolipoprotein A-I; Short=Apo-AI; Short=ApoA-I; AltName: Full=Apolipoprotein A1; Contains: RecName: Full=Proapolipoprotein A-I; Short=ProapoA-I; Contains: RecName: Full=Truncated apolipoprotein A-I; AltName: Full=Apolipoprotein A-I(1-242); Flags: Precursor; Gene name Name=APOA1 Encoded on Name=APOA1 Keywords 3D-structure; Amyloid; Amyloidosis; Atherosclerosis; Cholesterol metabolism; Complete proteome; Direct protein sequencing; Disease mutation; Glycation; Glycoprotein; HDL; Lipid metabolism; Lipid transport; Lipoprotein; Neuropathy; Oxidation; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Steroid metabolism; Sterol metabolism; Transport. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL J00098; AAB59514.1; -; Genomic_DNA EMBL X01038; CAA25519.1; -; Genomic_DNA EMBL X02162; CAA26097.1; -; mRNA EMBL X00566; CAA25232.1; -; mRNA EMBL M11791; AAA35545.1; -; mRNA EMBL X07496; CAA30377.1; -; Genomic_DNA EMBL M27875; AAA62829.1; -; mRNA EMBL M29068; AAA51747.1; -; mRNA EMBL AY422952; AAQ91811.1; -; Genomic_DNA EMBL AY555191; AAS68227.1; -; Genomic_DNA EMBL A14829; CAA01198.1; -; mRNA EMBL AK292231; BAF84920.1; -; mRNA EMBL EF444948; ACA05932.1; -; Genomic_DNA EMBL EF444948; ACA05933.1; -; Genomic_DNA EMBL EF444948; ACA05934.1; -; Genomic_DNA EMBL EF444948; ACA05935.1; -; Genomic_DNA EMBL EF444948; ACA05936.1; -; Genomic_DNA EMBL CH471065; EAW67274.1; -; Genomic_DNA EMBL BC005380; AAH05380.1; -; mRNA EMBL BC110286; AAI10287.1; -; mRNA CCDS CCDS8378.1; -; . PIR A90947; LPHUA1; . RefSeq NP_000030.1; NM_000039.2; . RefSeq NP_001304946.1; NM_001318017.1; . RefSeq NP_001304947.1; NM_001318018.1; . RefSeq NP_001304950.1; NM_001318021.1; . UniGene Hs.93194; -; . PDB 1AV1; X-ray; 4.00 A; A/B/C/D=68-267 PDB 1GW3; NMR; -; A=166-211 PDB 1GW4; NMR; -; A=166-211 PDB 1ODP; NMR; -; A=190-209 PDB 1ODQ; NMR; -; A=190-209 PDB 1ODR; NMR; -; A=190-209 PDB 2A01; X-ray; 2.40 A; A/B/C=25-267 PDB 2MSC; NMR; -; A/C=68-265 PDB 2MSD; NMR; -; A/C=68-265 PDB 2MSE; NMR; -; A/C=68-265 PDB 2N5E; NMR; -; A/B=79-267 PDB 3K2S; X-ray; -; A/B=25-267 PDB 3R2P; X-ray; 2.20 A; A=25-208 PDB 4V6M; EM; 7.10 A; A0/A1=68-267 PDBsum 1AV1; -; . PDBsum 1GW3; -; . PDBsum 1GW4; -; . PDBsum 1ODP; -; . PDBsum 1ODQ; -; . PDBsum 1ODR; -; . PDBsum 2A01; -; . PDBsum 2MSC; -; . PDBsum 2MSD; -; . PDBsum 2MSE; -; . PDBsum 2N5E; -; . PDBsum 3K2S; -; . PDBsum 3R2P; -; . PDBsum 4V6M; -; . ProteinModelPortal P02647; -; . SMR P02647; -; . BioGrid 106832; 90; . DIP DIP-29619N; -; . IntAct P02647; 70; . MINT MINT-5000866; -; . STRING 9606.ENSP00000236850; -; . ChEMBL CHEMBL5984; -; . iPTMnet P02647; -; . PhosphoSitePlus P02647; -; . BioMuta APOA1; -; . DMDM 113992; -; . DOSAC-COBS-2DPAGE P02647; -; . OGP P02647; -; . REPRODUCTION-2DPAGE IPI00021841; -; . REPRODUCTION-2DPAGE P02647; -; . SWISS-2DPAGE P02647; -; . UCD-2DPAGE P02647; -; . EPD P02647; -; . MaxQB P02647; -; . PaxDb P02647; -; . PeptideAtlas P02647; -; . PRIDE P02647; -; . DNASU 335; -; . Ensembl ENST00000236850; ENSP00000236850; ENSG00000118137; . Ensembl ENST00000359492; ENSP00000352471; ENSG00000118137; . Ensembl ENST00000375320; ENSP00000364469; ENSG00000118137; . Ensembl ENST00000375323; ENSP00000364472; ENSG00000118137; . GeneID 335; -; . KEGG hsa:335; -; . UCSC uc001ppv.2; human; . CTD 335; -; . DisGeNET 335; -; . GeneCards APOA1; -; . HGNC HGNC:600; APOA1; . HPA CAB016778; -; . HPA HPA046715; -; . MalaCards APOA1; -; . MIM 105200; phenotype; . MIM 107680; gene+phenotype; . MIM 205400; phenotype; . MIM 604091; phenotype; . neXtProt NX_P02647; -; . OpenTargets ENSG00000118137; -; . Orphanet 425; Apolipoprotein A-I deficiency; . Orphanet 93560; Familial renal amyloidosis due to Apolipoprotein AI variant; . Orphanet 314701; Primary systemic amyloidosis; . PharmGKB PA49; -; . eggNOG ENOG410IWKR; Eukaryota; . eggNOG ENOG410YGQ6; LUCA; . GeneTree ENSGT00530000063081; -; . HOGENOM HOG000033998; -; . HOVERGEN HBG105708; -; . InParanoid P02647; -; . KO K08757; -; . OMA KDFATVY; -; . OrthoDB EOG091G0IA5; -; . PhylomeDB P02647; -; . TreeFam TF334458; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-1369062; ABC transporters in lipid homeostasis; . Reactome R-HSA-174800; Chylomicron-mediated lipid transport; . Reactome R-HSA-194223; HDL-mediated lipid transport; . Reactome R-HSA-1989781; PPARA activates gene expression; . Reactome R-HSA-2168880; Scavenging of heme from plasma; . Reactome R-HSA-3000471; Scavenging by Class B Receptors; . Reactome R-HSA-3000480; Scavenging by Class A Receptors; . Reactome R-HSA-975634; Retinoid metabolism and transport; . Reactome R-HSA-977225; Amyloid fiber formation; . ChiTaRS APOA1; human; . EvolutionaryTrace P02647; -; . GeneWiki Apolipoprotein_A1; -; . GenomeRNAi 335; -; . PMAP-CutDB P02647; -; . PRO PR:P02647; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000118137; -; . CleanEx HS_APOA1; -; . ExpressionAtlas P02647; baseline and differential; . Genevisible P02647; HS; . GO GO:0072562; C:blood microparticle; IDA:UniProtKB; . GO GO:0009986; C:cell surface; IEA:Ensembl; . GO GO:0042627; C:chylomicron; IBA:GO_Central; . GO GO:0031410; C:cytoplasmic vesicle; IDA:BHF-UCL; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0034365; C:discoidal high-density lipoprotein particle; IEA:Ensembl; . GO GO:0005769; C:early endosome; TAS:Reactome; . GO GO:0030139; C:endocytic vesicle; IDA:BHF-UCL; . GO GO:0071682; C:endocytic vesicle lumen; TAS:Reactome; . GO GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:1903561; C:extracellular vesicle; IDA:UniProtKB; . GO GO:0034364; C:high-density lipoprotein particle; IDA:BHF-UCL; . GO GO:0005634; C:nucleus; IEA:Ensembl; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:0034366; C:spherical high-density lipoprotein particle; IDA:BHF-UCL; . GO GO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL; . GO GO:0034191; F:apolipoprotein A-I receptor binding; IPI:BHF-UCL; . GO GO:0034190; F:apolipoprotein receptor binding; IPI:BHF-UCL; . GO GO:0001540; F:beta-amyloid binding; IDA:BHF-UCL; . GO GO:0045499; F:chemorepellent activity; IDA:UniProtKB; . GO GO:0015485; F:cholesterol binding; IDA:BHF-UCL; . GO GO:0017127; F:cholesterol transporter activity; IMP:BHF-UCL; . GO GO:0019899; F:enzyme binding; IPI:BHF-UCL; . GO GO:0008035; F:high-density lipoprotein particle binding; IEA:Ensembl; . GO GO:0070653; F:high-density lipoprotein particle receptor binding; IPI:BHF-UCL; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0055102; F:lipase inhibitor activity; IEA:Ensembl; . GO GO:0031210; F:phosphatidylcholine binding; IBA:GO_Central; . GO GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IDA:BHF-UCL; . GO GO:0005543; F:phospholipid binding; IDA:BHF-UCL; . GO GO:0005548; F:phospholipid transporter activity; IEA:Ensembl; . GO GO:0030325; P:adrenal gland development; IEA:Ensembl; . GO GO:0031100; P:animal organ regeneration; IEA:Ensembl; . GO GO:0043534; P:blood vessel endothelial cell migration; IEA:Ensembl; . GO GO:0044267; P:cellular protein metabolic process; TAS:Reactome; . GO GO:0006695; P:cholesterol biosynthetic process; IBA:GO_Central; . GO GO:0033344; P:cholesterol efflux; IDA:BHF-UCL; . GO GO:0042632; P:cholesterol homeostasis; IDA:BHF-UCL; . GO GO:0070508; P:cholesterol import; IMP:BHF-UCL; . GO GO:0008203; P:cholesterol metabolic process; IMP:BHF-UCL; . GO GO:0030301; P:cholesterol transport; IDA:MGI; . GO GO:0001935; P:endothelial cell proliferation; IEA:Ensembl; . GO GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:BHF-UCL; . GO GO:0008211; P:glucocorticoid metabolic process; IEA:Ensembl; . GO GO:0034380; P:high-density lipoprotein particle assembly; IDA:BHF-UCL; . GO GO:0034384; P:high-density lipoprotein particle clearance; IC:BHF-UCL; . GO GO:0034375; P:high-density lipoprotein particle remodeling; IDA:BHF-UCL; . GO GO:0007229; P:integrin-mediated signaling pathway; IDA:UniProtKB; . GO GO:0019915; P:lipid storage; IEA:Ensembl; . GO GO:0042158; P:lipoprotein biosynthetic process; TAS:Reactome; . GO GO:0042157; P:lipoprotein metabolic process; IBA:GO_Central; . GO GO:0050919; P:negative chemotaxis; IDA:UniProtKB; . GO GO:0060354; P:negative regulation of cell adhesion molecule production; IDA:BHF-UCL; . GO GO:0002740; P:negative regulation of cytokine secretion involved in immune response; IDA:BHF-UCL; . GO GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IDA:BHF-UCL; . GO GO:0050728; P:negative regulation of inflammatory response; IDA:BHF-UCL; . GO GO:0050713; P:negative regulation of interleukin-1 beta secretion; IDA:BHF-UCL; . GO GO:0060192; P:negative regulation of lipase activity; IEA:Ensembl; . GO GO:0060761; P:negative regulation of response to cytokine stimulus; IDA:BHF-UCL; . GO GO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; IDA:BHF-UCL; . GO GO:0010903; P:negative regulation of very-low-density lipoprotein particle remodeling; IDA:BHF-UCL; . GO GO:0031102; P:neuron projection regeneration; IBA:GO_Central; . GO GO:0018206; P:peptidyl-methionine modification; IDA:UniProtKB; . GO GO:0014012; P:peripheral nervous system axon regeneration; IEA:Ensembl; . GO GO:0006656; P:phosphatidylcholine biosynthetic process; IDA:BHF-UCL; . GO GO:0033700; P:phospholipid efflux; IDA:BHF-UCL; . GO GO:0055091; P:phospholipid homeostasis; IDA:BHF-UCL; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0010873; P:positive regulation of cholesterol esterification; IDA:BHF-UCL; . GO GO:0045723; P:positive regulation of fatty acid biosynthetic process; IBA:GO_Central; . GO GO:0051345; P:positive regulation of hydrolase activity; IDA:BHF-UCL; . GO GO:0051006; P:positive regulation of lipoprotein lipase activity; IBA:GO_Central; . GO GO:0035025; P:positive regulation of Rho protein signal transduction; IDA:UniProtKB; . GO GO:0051496; P:positive regulation of stress fiber assembly; IDA:UniProtKB; . GO GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IDA:UniProtKB; . GO GO:0010898; P:positive regulation of triglyceride catabolic process; IBA:GO_Central; . GO GO:0018158; P:protein oxidation; IDA:UniProtKB; . GO GO:0050821; P:protein stabilization; IDA:BHF-UCL; . GO GO:0006898; P:receptor-mediated endocytosis; TAS:Reactome; . GO GO:0032489; P:regulation of Cdc42 protein signal transduction; IDA:BHF-UCL; . GO GO:0030300; P:regulation of intestinal cholesterol absorption; IBA:GO_Central; . GO GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl; . GO GO:0042493; P:response to drug; IEA:Ensembl; . GO GO:0043627; P:response to estrogen; IEA:Ensembl; . GO GO:0007584; P:response to nutrient; IEA:Ensembl; . GO GO:0001523; P:retinoid metabolic process; TAS:Reactome; . GO GO:0043691; P:reverse cholesterol transport; IMP:BHF-UCL; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0019433; P:triglyceride catabolic process; IBA:GO_Central; . GO GO:0070328; P:triglyceride homeostasis; IDA:BHF-UCL; . GO GO:0051180; P:vitamin transport; IMP:AgBase; . InterPro IPR000074; ApoA_E; . Pfam PF01442; Apolipoprotein; 1; .

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